Matrix metalloproteases expression in different histological types of colorectal polyps

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Matrix metalloproteases expression in different histological types of colorectal polyps.

INTRODUCTION Colorectal carcinoma (CC) may begin as benign polyps, which may be classified in different histological types with a different risk to develop cancer. Matrix metalloproteases (MMPs) are able to degrade all components in the extracellular matrix and are important tissue-remodeling enzymes and key elements in tumor invasion and metastasis. The aim of this study was to investigate the...

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COLORECTAL POLYPS: EVALUATION IN TWO YEARS

From June 1989, to June 1991, 58 patients with GI polyps were reviewed. Except two patients who had multiple polyps, 56 had only one polyp. The size of polyps were 0.5 to 3 em in diameter. 51 (75%) of polyps were located in the rectosigmoid region, 25 (37%) were in the rectum and 26 (38%) in the sigmoid. (Seventeen) (25%) polyps (two in right colon, four in transverse, and 11 in descending...

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Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins

Fibroblasts are widely distributed cells and are responsible for the deposition of extracellular matrix (ECM) components but also secrete ECM-degrading matrix metalloproteases. A finely balanced equilibrium between deposition and degradation of ECM is essential for structural integrity of tissues. In the past, fibroblasts have typically been understood as a uniform cell population with comparab...

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Malignant Colorectal Polyps; Pathological Consideration (A review)

Background: Routine screening colonoscopy is on the rise and pathologists have to deal with the ever larger numbers of excised colonic polyps. It is very important to optimize the patients’ individual treatment and further surveillance. Pathologists play a critical role in management, as most of the clinical decisions concerning colonic polyp managemen...

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Historical perspective of matrix metalloproteases.

Matrix metalloproteinases (MMPs) were identified as early as 1962. Since this seminal finding, this family of zinc-dependent endopeptidases has been studied extensively. This collective work has resulted in delineation of MMP gene and protein structures, the mechanisms of control of MMPs, the action of MMPs on both extracellular matrices and other proteins such as growth factors and cytokines, ...

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ژورنال

عنوان ژورنال: Revista Española de Enfermedades Digestivas

سال: 2017

ISSN: 1130-0108

DOI: 10.17235/reed.2017.4551/2016